Sintesis Tak Organik

This research program focuses on inorganic compounds, with an emphasis on the discovery/development of new, efficient synthetic methodologies, and on the synthesis of complex and/or challenging molecules. Generally, the synthetic targets involve novel structures displaying unique properties. Coordination compounds of particular interest are those that show biological activities. Investigations into the interaction of small molecules with DNA are of particular interest and this has led to the discovery of many potentially therapeutic agents, including antibacterial and anticancer drugs. Luminescent and redox active metal complexes have been structurally and physically characterized for their use as DNA probes. One of the goals is to determine the structure-biological activity relationship of the compounds synthesized using computational studies.

Information on Key Researchers:




Inorganic Synthesis


Dr. Mohamed Ibrahim Mohamed Tahir


Coordination Chemistry

Dr. Mohamed Ibrahim Mohamed Tahir

Assoc. Prof. Dr. Haslina Ahmad

Assoc. Prof. Dr. Thahira Begum

En. Ahmad Zaidi Ismail

Materials Chemistry

Assoc. Prof. Dr. Tan Kar Ban

Prof. Dr. Zulkarnain Zainal

Assoc. Prof. Dr. Haslina Ahmad

Dr. Tan Yen Ping

Dr. Mohd Izham Saiman

Keywords: Synthesis, Inorganic compounds, Coordination Compounds, Bioactive Compounds, Computational Study

Research Highlights

The group has published several articles in high impact journals including some recent Publications:

• Ahmad, H., Ghosh, D. and Thomas, J. A. (2014). Using ancillary ligands to tune the DNA binding properties of self-assembled luminescent metallomacrocycles, Chemical Communication, 50, 3829

• Ahmad, H., Wragg, A., Cullen, W., Wombwell, C., Meijer, A. J. H. M. and Thomas, J. A. (2014) From Intercalation to Groove Binding: Switching the DNA-Binding Mode of Isostructural Transition-Metal Complexes, Chemistry – A European Journal, 20, 3089-3096.

• Omar, S.A., Ravoof, Thahira BSA, M.Tahir, M. I. and Crouse, K.A. (2014) Synthesis and characterization of mixed-ligand copper(II) saccharinate complexes containing tridentate NNS Schiff bases. X-ray crystallographic analysis of the free ligands and one complex,Transition Metal Chemistry, 39, 119-126

• Mazlan, N.A., Ravoof , Thahira BSA, M.Tahir, M. I., Crouse, K.A., Tiekink , E.R. and Veerakumarasivam, A. (2014) Mixed-ligand metal complexes containing an ONS Schiff base and imidazole/benzimidazole ligands: synthesis, characterization, crystallography and biological activity,Transition Metal Chemistry, 39, 633-639

A total of RM 717,000 thus far has been awarded to the group from various agencies such as MOSTI, MOHE and also UPM to conduct the research.

Links to Field of Study
Inorganic Chemistry
Computational Chemistry